5/27/2023 0 Comments Spine with disk map![]() ĭegenerative disc disease, caused by an irreversible decay of the IVD structural integrity, leads to an inadequate biomechanical response to pressure or load. The intervertebral disc (IVD) is mainly composed of an inherent architecture of dense collagen fibers, the annulus fibrosus, surrounding the nucleus pulposus with its high concentration of glycosaminoglycans (GAG) that facilitate its water-storing capabilities. Lower back pain (LBP) still ranks as the most common cause for years lived with disability (YLD) and disability-adjusted life years (DALY) according to the Global Burden of Disease Studies of 2016. The investigated T 2 mapping techniques differed significantly in discs with and without annular tearing (all p T 2-GRAPPATINI, T 2-MESE, T 2-EVEN, and T 2-WO1ST of the nucleus pulposus of normal discs differed significantly from those of discs with bulging or herniation (all p GRAPPATINI facilitates the use of T 2 values as quantitative imaging biomarkers to detect disc pathologies such as degeneration, lumbar disc herniation, and annular tears while simultaneously shortening the acquisition time from 13:18 to 2:27 min. The nucleus pulposus’ T 2 at different degeneration states showed significant differences between all group comparisons of Pfirrmann grades for T 2-GRAPPATINI ( p = 0.000–0.018), T 2-MESE ( p = 0.000–0.015), T 2-EVEN ( p = 0.000–0.019), and T 2-WO1ST ( p = 0.000–0.015). ![]() There was a significant difference between T 2-GRAPPATINI, T 2-MESE, T 2-EVEN, and T 2-WO1ST of discs with and without an annular tear for the nucleus pulposus (all p < 0.001). ![]() For the posterior annular region, only T 2-GRAPPATINI showed a significant difference ( p = 0.011) between normal and herniated discs. T 2-GRAPPATINI, T 2-MESE, T 2-EVEN, and T 2-WO1ST of the nucleus pulposus of normal discs differed significantly from those of bulging discs or herniated discs (all p < 0.001). The resulting T 2 values were compared for all four measurements. Segmentation was done on the four most central slices. Additional T 2 maps were calculated after discarding the first echo (T 2-WO1ST) and only using even echoes (T 2-EVEN). GRAPPATINI was conducted with the same parameters as a conventional 2D multi-echo spin-echo (MESE) sequence in 02:27 min instead of 13:18 min. This cohort study consisted of 19 patients, 20 rowers, and 19 volunteers. Methodsįifty-eight individuals (26 females, 32 males, age 23.3 ± 8.0 years) were prospectively examined at 3 T. This study evaluates GRAPPATINI, an accelerated T 2 mapping sequence combining undersampling and model-based reconstruction to facilitate the clinical implementation of T 2 mapping of the lumbar intervertebral disc.
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